I've been working with the Mach-II framework for a few weeks now, and I must say I'm EXTREMELY impressed. I had previously worked quite a bit with the MVCF methodology that Benoit Hediard created, but Mach-II takes CFC use and application architecture to a whole new level.
Mach-II was created by Hal Helms (of Fusebox fame) and Ben Edwards, and it's an event-based framework that uses implicit invocation (hence the "II"), directly supports the MVC design pattern, and encourages the creation of highly cohesive, loosely-coupled objects, so application maintenance and the addition of new functionality is a breeze. If you're using CFMX and you haven't yet looked into Mach-II, you really should. I wasn't ever a real fan of Fusebox but I honestly can't say enough good things about Mach-II based on my experience with it thus far.
Here are some additional links for more information: